![]() Geospatial Resolution of Human and Bacterial Diversity from City-scale Metagenomics. ![]() PMID: 26121404Īfshinnekoo E, Meydan C, Chowdhury S, Jaroudi D, Boyer C, Bernstein N, Maritz JM, Reeves D, Gandara J, Chhangawala S, Ahsanuddin S, Simmons A, Nessel T, Sundaresh B, Pereira E, Jorgensen E, Kolokotronis S, Kirchberger N, Garcia I, Gandara D, Dhanraj S, Nawrin T, Saletore Y, Alexander N, Vijay P, Hénaff EM, Zumbo P, Walsh M, O’Mullan GD, Tighe S, Dudley JT, Dunaif A, Ennis S, O’Halloran E, Magalhaes TR, Boone B, Jones AL, Muth TR, Paolantonio KS, Alter E, Schadt EE, Garbarino J, Prill RJ, Carlton JM, Levy S, Mason CE. Assembly and diploid architecture of an individual human genome via single-molecule technologies. Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, Durrett RE, Blanchard SC, Altman R, Chin CS, Guo Y, Paxinos EE, Korbel JO, Darnell RB, McCombie WR, Kwok PY, Mason CE, Schadt EE, Bashir A. Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Li S, Garrett-Bakelman FE, Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, Lewis ID, To LB, Delwel R, Löwenberg B, Döhner H, Döhner K, Guzman ML, Hassane DC, Roboz GJ, Grimwade D, Valk PJ, D'Andrea RJ, Carroll M, Park CY, Neuberg D, Levine R, Melnick AM, Mason CE. Nature Partner Journals (npj) Microgravity 2016 (in press) McIntyre ABR, Rizzardi L, Yu AM, Alexander N, Rosen GL, Botkin DJ, Stahl SS, John KK, Castro-Wallace SL, McGrath K, Burton AS, Feinberg AP, Mason CE. My TEDMED talk, “Discovering and designing genomes for Earth, Mars, and beyond,” is here: Many educational and outreach talks are given about this work, from elementary schools, high schools, and to conferences like ASHG, AGBT, and other venues like TEDMED. We are working to engineer complex environmental systems, microbiomes, and/or biofilms for protective purposes ( and ) and also study extremophiles as models for unique adaptations for potential life in extreme environments that we might encounter on other worlds ( ).ĥ ) Space Genetics Education and Outreach Weill Cornell Medicine now has space mission training and data analytics courses for space experiments as a formal Area of Concentration (AOC) that medical and graduate students can take while getting their M.D or PhD.: We also have one other grant looking at cell-to-cell changes in epigenetics and chromatin (single cell ATAC-seq), which will use the NASA Twins samples as well as that of other astronauts:ģ) Medical Student Training for Space Genomics Assays include: phased whole genome sequencing (WGS), deep exome sequencing (WES), small and large RNA-sequencing, epigenome sequencing with whole genome bisulfite sequencing (WGBS) for methylation (mC) and hydroxy-methylation (hmC) changes, epitranscriptome profiling, proteomics (LC-MS), antibody titers, telomere length, metabolomics, microbiome, cognition, and vasculature measures. This includes a 19-time point, multi-tissue and microbiome monitoring across two years: 6 months before launch, 12 months in space, and 6 months after return to Earth. Our lab was one of ten chosen by NASA to focus on a complete systems biology, molecular portrait of the impact of long-term space travel on the human body, leveraging a multi-omics approach leveraging the latest in genome technologies and computational methods. This was after a proof-of-principle experiment showed for the first time that is it indeed possible to sequence in zero gravity:Ģ) The NASA Twins Study and Single-cell, Epigenetic Dynamics of Space Travel Our mission just completed the first-ever sequencing of DNA in space on the international space station in August-September 2016. 1) The Biomolecule Sequencer (BSeq) Project with NASA
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